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延迟对幽门螺杆菌感染的再治疗会增加上消化 [复制链接]

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每周二、四为您推送近期幽门螺杆菌相关文献摘要,追踪学术进展。

DelayinretreatmentofHelicobacterpyloriinfectionincreasesriskofUpperGastrointestinalBleeding

延迟对幽门螺杆菌感染的再治疗会增加上消化道出血的风险

Abstract摘要

BackgroundandAims/p>

Littleisknownaboutriskofuppergastrointestinalbleeding(UGIB)inpatientsfailedbyHelicobacterpylorieradicationtherapy.Weinvestigatedtheeffectsofdifferenttimeuntilretreatment,afterfailureofinitialH.pylorieradicationtherapy,onsubsequentriskofUGIB.

背景和目的:

人们对幽门螺杆菌根除疗法失败的患者发生上消化道出血(UGIB)的风险知之甚少。我们研究了初次幽门螺杆菌根除治疗失败后,直至再治疗的不同时间对后续UGIB风险的影响。

Methods/p>

Weperformedaterritory-wideretrospectivecohortstudyof70,patientswithHpyloriinfectionwhohadreceivedtheirfirstcourseofclarithromycin-basedtripletherapyfromJanuarythroughDecemberinHongKong.Patientswhorequiredretreatmentafterfailedinitialtherapy(n=,11.8%)werecategorizedbasedontimebetweeninitialandfinalHpylorieradication(3monthsorless,3–12months,andmorethan12months).Wecollectedclinicaldatafrom30daysafterprescriptionofthelastcourseofHpyloritherapyuntilhospitalizationfornon-varicealUGIB,death,ortheendofthestudy(30Jun;medianfollow-uptime,7.65years).Theprimaryout

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